Annual review of public health submission

Annual review of public health submission


 Epidemiologic and experimental evidence reviewed in this article emphasizes the complex and multifactorial etiology of endemic goiter. The important role of iodine deficiency as an etiologic factor in endemic goiter is firmly established, but there is evidence that other environmental factors can play an equally important role in the pathogenesis of this condition. Chemical categories, sources, and sites of action of the various classes of naturally occurring goitrogens and antithyroid agents are reviewed in this article. Evidence of the presence of these compounds in foodstuffs and drinking water is discussed. Bacterial contamination of water supplies also appears to be important in the development of goiter. Microorganisms appear to intervene in the biosynthesis and degradation of organic goitrogenic pollutants or may induce thyroid growth-promoting activity in the host, or both. Malnutrition and poor socioeconomic conditions, as for iodine deficiency, enhance the action of environmental goitrogens. Thus, a coordinated multidisciplinary approach is essential to solving this public health problem
AIMS AND SCOPE OF JOURNAL: The Annual Review of Public Health, in publication since 1980, covers significant developments within the field of public health, including key developments and issues in epidemiology and biostatistics, environmental and occupational health, social environment and behavior, health services, and public health practice and policy. Volume 41 (2020) has been converted from gated to open access through Annual Reviews’ subscribe Open program, with all articles published under a CC BY license. the rear volumes, dating from 1980, are now freely available [Volumes 38 (2017) and 39 (2018) are available open access under CC BY license through support from the Robert Wood Johnson Foundation]

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